# The Guarding U.S. Medicare Against Rising Drug Costs (GUARD) Model and the Global Benchmark for Efficient Drug Pricing (GLOBE) Model would require manufacturer rebates.

*biotech · news · 2025-12-22 · Benzinga*

## Key points

- CMS proposed two mandatory models, GUARD and GLOBE, to tie Medicare drug prices to international benchmarks.
- GUARD targets Medicare Part D drugs and would require manufacturer rebates when U.S. prices exceed international prices.
- GLOBE would apply similar international price benchmarking to select Medicare Part B drugs starting October 1, 2026.
- Both models will use manufacturer-reported international pricing data to determine required rebate amounts.

**Countries:** United States

[Read the full story on Benzinga](https://www.benzinga.com/news/health-care/25/12/49542916/us-government-looks-abroad-to-tame-medicare-drug-prices-with-new-guard-globe-models)

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