# Pfizer shares were down 1.3% at $25.70 at the time of publication on Monday.

*biotech · news · 2026-06-08 · Benzinga*

## Key points

- Pfizer's berobenatide showed a 15.9% non-placebo-adjusted weight loss at 32 weeks in Phase 2b.
- Pfizer presented first clinical results with berobenatide's top weekly dose at this update.
- The pivotal Phase 3 trial for berobenatide is now enrolling participants for obesity treatment.
- Pfizer plans ten additional Phase 3 studies of berobenatide in 2026 targeting various comorbidities.
- HYMPAVZI's FDA indication now includes pediatric hemophilia B patients aged 6 to 11 years.

Pfizer Berobenatide Update On Saturday, the company reported that the Phase 2b studies for berobenatide demonstrated a non-placebo-adjusted weight loss of 15.9% in participants. The pivotal Phase 3 study is currently open for enrollment, which may further bolster Pfizer’s position in the obesity treatment market. Pfizer plans to advance 10 Phase 3 studies for berobenatide in 2026 for chronic weight management and obesity-related comorbidities, including knee osteoarthritis and obstructive sleep apnea, as part of a broader program of 20+ obesity trials. The first clinical experience with the top weekly dose for berobenatide is were presented for the first time. Results from a 32-week exploratory extension (Part B) of the Phase 2b VESPER-1 study showed a non-placebo-adjusted weight loss of 15.9% with no plateau observed at 32 weeks on berobenatide (Week 60 of the overall study), in participants who escalated from placebo to 2.4 mg weekly berobenatide. Phase 3 Program Expands FDA Expands HYMPAVZI Indication HYMPAVZI is the first subcutaneous non-factor therapy available for pediatric patients with hemophilia B aged 6 to 11 years. PFE Stock Price Activity: Pfizer shares were down 1.3% at $25.70 at the time of publication on Monday, according to Benzinga Pro data. Photo: Molly Woodward / Shutterstock

**Companies:** Pfizer
**Countries:** United States

[Read the full story on Benzinga](https://www.benzinga.com/news/health-care/26/06/53069479/pfizers-obesity-drug-shows-16-weight-loss-in-phase-2b-study)

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