# Scientists have identified a protein in the body that may influence the progression of alcohol-associated liver disease and drinking behavior.

*business · news · 2026-04-08 · Medical Xpress*

## Key points

- AQP9 facilitates acetaldehyde entry into the liver, worsening early-stage alcohol-related liver damage.
- Mice lacking AQP9 showed reduced binge-like alcohol consumption and delayed acetaldehyde clearance.
- AQP9 levels are significantly lower in humans with advanced alcohol-associated liver diseases.
- Reduced AQP9 leads to increased liver cell death and advanced disease due to prolonged acetaldehyde toxicity.
- AQP9 is identified as a potential therapeutic target for treating advanced liver disease and alcohol use disorder.

[Read the full story on Medical Xpress](https://medicalxpress.com/news/2026-04-potential-therapeutic-alcohol-liver-disease.html)

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